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Mitochondria and COVID-19

2/21/2023

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Mitochondrial health has been implicated as a potential contributor to the symptoms of long COVID. 

Mitochondria are tiny organelles found within cells that play a critical role in human health. They are often referred to as the "powerhouses" of the cell because they generate most of the cell's energy. This energy is essential for many cellular processes: the regulation of the immune system, the regulation of inflammation, and the maintenance of healthy tissues and organs. Additionally, mitochondria play a role in programmed cell death (apoptosis), which is necessary for removing damaged or abnormal cells. Overall, maintaining the health and function of mitochondria is important for maintaining overall health and preventing disease. Dysfunction in mitochondrial health has been linked to several diseases including neurological disorders, cardiovascular disease, and metabolic disorders. Mitochondria also play a crucial role in the functioning of our immune system. 

The mechanisms by which mitochondrial health may contribute to long COVID are still being explored. 

SARS-CoV-2 the virus that causes COVID-19 effects mitochondrial functions. These manipulations of our mitochondria can release mitochondrial DNA into the cytoplasm of a cell which activates something called the inflammasome and suppresses both our innate and adaptive immunity.1 In a nutshell, it appears that SARS-CoV-2 uses our own mitochondrial for it’s benefit leaving behind inflammation and a suppressed immune response. 

Reactivated viruses including Epstein-Barr Virus (EBV) and Human Herpes Virus 6 (HHV-6) have been found in patients with long COVID. EBV and HHV-6 can lead to mitochondrial fragmentation which impacts our ability to produce energy.2 This might explain the potential symptom of exercise intolerance in long COVID patient. 

Mitochondrial health is just one of many factors likely contributing to long COVID symptoms. 

We can support mitochondrial health in a variety of ways:
  1. Eating a healthy diet: a diet rich in nutrients including antioxidants, B vitamins, and Coenzyme Q10, can support mitochondrial health.
  2. Regular exercise: physical activity has been shown to increase the number of mitochondria in cells and improve their function.
  3. Getting enough sleep: Sleep is important for overall health and has been shown to have a positive impact on mitochondrial function.
  4. Avoiding toxins: Exposure to toxins, including alcohol, drugs, and environmental pollutants, can damage mitochondria and reduce their function.
  5. Taking supplements: Some supplements including antioxidants (e.g., Vitamin C, E, and alpha-lipoic acid) and Coenzyme Q10, may support mitochondrial health. However, it is important to talk to a healthcare provider before taking any supplements.
  6. Managing stress: Chronic stress can contribute to mitochondrial dysfunction. Managing stress through practices such as meditation, yoga, or exercise can help support mitochondrial health.

Exercise is important not just because it increases the number of mitochondria but also because of myokine production. Myokines are signaling molecules that are produced by muscle cells and play a role in regulating various biological processes in the body. They are released during physical activity and can act locally on muscle cells or travel to other tissues in the body to influence metabolic, immune, and endocrine function. The mitochondria signal to each other using myokines.3 When patients are too fatigued for cardiovascular exercise I often recommend very gentle strength training to encourage muscle growth and increase the number of myokines being produced. 


References:
  1. Singh , K.K., Chaubey , G., Chen , J.Y., and Suravajhala , P. (2020). Decoding SARS-CoV-2 hijacking of host mitochondria in COVID-19 pathogenesis. Am J Physiol Cell Physiol 319, C258–C267. 
  2. Davis HE, McCorkell L, Vogel JM, Topol EJ. Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol. 2023 Mar;21(3):133-146. doi: 10.1038/s41579-022-00846-2. Epub 2023 Jan 13. PMID: 36639608; PMCID: PMC9839201.
  3.  Nunn AVW, Guy GW, Botchway SW, Bell JD. SARS-CoV-2 and EBV; the cost of a second mitochondrial "whammy"? Immun Ageing. 2021 Oct 30;18(1):40. doi: 10.1186/s12979-021-00252-x. PMID: 34717676; PMCID: PMC8556816.



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Long Covid and the Epstein-Barr Virus

2/8/2023

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​Long COVID or Post COVID Conditions (PCC) can include a wide range of ongoing health concerns after a COVID infection that can last for months or even years. 

General symptoms include:
  • Fatigue that interferes with daily life
  • Symptoms that are worse after physical or mental activity
  • Brain fog
  • Sleep difficulty
  • Gastrointestinal complaints
  • Joint pain
  • Muscle pain
  • Headaches
  • Fever
  • Skin rashes

These symptoms are similar to ME/CFS (myalgic encephalomyelitis/chronic fatigue syndrome) and other chronic illnesses that can occur after infections (1). 

Having lasting symptoms after an infection isn’t new. In naturopathic medicine when we treat patients who have prolonged fatigue, joint pain and brain fog we test for Epstein-Barr virus reactivation as one of the potential causes.  

The Epstein-Barr Virus (EBV) is part of the herpes family of viruses and is the main virus behind a mononucleosis infection. EBV is very prevalent because it’s easily spread via saliva and estimates are that 90% of the world’s population is infected with this virus. Once we have been exposed to the Epstein-Barr virus it lives in our bodies indefinitely. EBV lives in human hosts between two distinctive phases called the lytic phase and latent phase. The lytic phase is the active phase of the virus when it’s causing infection. The latent phase is a truce between our immune system and the virus during which time only a small number of viral genes are expressed. EBV reactivates to the lytic phase when we are under psychological stress that weakens our immune system and reactivation has been shown to occur in individuals experiencing certain cancers, autoimmune diseases and chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) (2). 

Reactivation of EBV has been linked to symptoms of long COVID. (3)

Research has found that 82% of patients critically ill with SARS-Cov-2 infections developed a reactivation of EBV. (4) One research study in 2021 randomly selected COVID-19 patients and analyzed their blood. They found that a very high proportion of patients that went on to develop long COVID symptoms tested positive for EBV reactivation. The patients with COVID-19 that did not develop long COVID symptoms had a very low percentage of EBV reactivation. (5) One factor in long COVID may be that EBV reactivates. 

Interestingly the symptoms of EBV reactivation are very similar to the symptoms of long COVID and include: (6)
  • Fatigue
  • Brain fog
  • Sleep disturbance
  • Joint pain
  • Sore throat
  • Muscle pain
  • Headaches
  • Fever
  • Gastrointestinal complaints
  • Various skin rashes 

We can test for EBV reactivation with blood tests that include EBV viral capsid antigen (VCA) IgM, EBV early antigen (EA-D) IgG. The EBV VCA IgM is usually only detectable during the acute state of the primary infection (when you were first ill with EBV) and can show up again with a reactivation. (7)

As researchers continue to unravel the mystery around long COVID symptoms this provides us some clues for how to support patients struggling with long COVID. For years naturopathic doctors have supported patients with EBV reactivation so we have somewhere to start. 

One thing to keep in mind with EBV reactivation is that this virus thrives on the stress hormone cortisol. EBV contains stretches of DNA that sense glucocorticoid (cortisol) levels. When levels are higher EBV reactivates. Stress management is a major player in our treatment plans. 

Stay tuned for more on long COVID, EBV reactivation and ways to support your body. 



References: 
  1. https://www.cdc.gov/coronavirus/2019-ncov/long-term-effects/index.html
  2. Kerr JR. Epstein-Barr virus (EBV) reactivation and therapeutic inhibitors. J Clin Pathol. 2019 Oct;72(10):651-658. doi: 10.1136/jclinpath-2019-205822. Epub 2019 Jul 17. PMID: 31315893.
  3. Chen, J., Song, J., Dai, L., Post, S. R., & Qin, Z. (2022). SARS‐CoV‐2 infection and lytic reactivation of herpesviruses: A potential threat in the postpandemic era? Journal of Medical Virology, 94(11), 5103-5111. https://doi.org/10.1002/jmv.27994 
  4. Simonnet A, Engelmann I, Moreau AS, Garcia B, Six S, El Kalioubie A, Robriquet L, Hober D, Jourdain M. High incidence of Epstein-Barr virus, cytomegalovirus, and human-herpes virus-6 reactivations in critically ill patients with COVID-19. Infect Dis Now. 2021 May;51(3):296-299. doi: 10.1016/j.idnow.2021.01.005. Epub 2021 Jan 18. PMID: 33495765; PMCID: PMC7816954.
  5. Gold JE, Okyay RA, Licht WE, Hurley DJ. Investigation of Long COVID Prevalence and Its Relationship to Epstein-Barr Virus Reactivation. Pathogens. 2021 Jun 17;10(6):763. doi: 10.3390/pathogens10060763. PMID: 34204243; PMCID: PMC8233978.
  6.  Straus S.E., Tosato G., Armstrong G., Lawley T., Preble O.T., Henle W., Davey R., Pearson G., Epstein J., Brus I., et al. Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Ann. Intern. Med. 1985;102:7–16. doi: 10.7326/0003-4819-102-1-7.
  7. Straus SE, Tosato G, Armstrong G, Lawley T, Preble OT, Henle W, Davey R, Pearson G, Epstein J, Brus I, et al. Persisting illness and fatigue in adults with evidence of Epstein-Barr virus infection. Ann Intern Med. 1985 Jan;102(1):7-16. doi: 10.7326/0003-4819-102-1-7. PMID: 2578268.
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My Experience with COVID

4/20/2022

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On the two-year anniversary of the WHO declaring a pandemic, I developed COVID-19. 

For me, it started with sinus congestion that escalated into a low-grade fever, sneezing, fatigue, sore throat, and a cough. My symptoms started on a Friday so I was able to rest through the weekend and then reschedule my patients for Monday and Tuesday. By Tuesday my fever was over and I was feeling a little better. Feeling confident that the worst was behind me, I went back to work on Wednesday. On Thursday I had a very long day of patients and suffered a setback in my recovery. By Thursday evening I lost my voice, my sore throat returned, and by Friday morning I became severely fatigued. 

I can’t overstate the need for rest when you are recovering from an illness, especially COVID-19. Doing too much too quickly can really set you back. This is exactly what happened to me. 

Personally, I find rest to be incredibly challenging. I am a person who feels the best when I am ticking things off my to-do list. I will do almost anything to avoid rescheduling patients. What I learned from my experience with COVID is that sometimes, I need to take my own advice and in this instance, I needed an entire week to really rest and recover. 

This experience has forced me to examine (again!) my deeply held beliefs regarding productivity and self-worth. It seems so simple. Rest when you are sick so you recover faster. In practice? It’s complicated. Resting means letting patients down. Resting means missing deadlines. Resting means really prioritizing what has to get done vs what can wait. 

As I write this, I am currently on day 18 and still struggling with fatigue. I made the decision to only see patients one day this week so I can rest. Making this decision is really swimming upstream: in the West, prioritizing health so we can recover more quickly - and completely - is counter-culture. I am often counseling patients about putting their needs first and this experience has really challenged me to ‘practice what I preach’. I have bought into the narrative that it’s virtuous to put other people before yourself. I’m reminded every time I fly and I hear the airline crew reciting the same old statement that we must put on our own oxygen mask first before assisting others. Yet I continue to work long hours, skip workouts, or stay up too late in service of doing a good job. COVID-19 was a wake up call for me. 

Please learn from my mistakes and give yourself the time you need to rest and recover!
​
I will also share some of the therapies I used to help myself recover. I am intentionally omitting supplements I utilized because herbs and nutrients aren’t one-size-fits-all so what I needed may not be what you need. 
  • Hydrotherapy 
  • Sleep 
  • A high antioxidant diet.
  • Cold socks and a fever bath were both really helpful in the early days of my illness. (If you aren’t familiar with the reasons we want to encourage and even prolong a low-grade fever check out my article here.)
  • I stayed very well hydrated by adding electrolyte powder to water and also adding fruits and greens powder to my water several times per day. 
  • My cough and congestion persisted long after my sore throat and fever resolved so I also used a steam inhalation with eucalyptus essential oil twice daily for a few days to help clear that up. I just boil water in a regular pot then move it to a table, put a few drops in the pot, sit down, place a towel over my head and breathe deeply.

I hope this encourages you to put your needs first and take good care of yourself when you are ill…and when you are well. 

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Hashimoto's Winter Research Update 2022

3/7/2022

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I regularly read through recent literature on autoimmune thyroid disease/Hashimoto's. I post about each of these studies on instagram as I review them and put it all together on this blog twice per year. 

You can use the categories located to the right of this post and click 'Hashimoto's Research Update' to see all of the updates.

TPO Antibodies and Quality of Life (https://pubmed.ncbi.nlm.nih.gov/21186954/)  (2011)

This study included 426 females who planned to undergo thyroid surgery. They only included participants whose TSH, FT3 and FT4 were in the normal range. TPO antibodies were tested prior to surgery and they examined the thyroid tissue that was removed. These women also took symptom and health questionnaires prior to surgery. 

The researchers found that the level of TPO antibodies correlated with the grade of thyroid inflammation. This makes a lot of common sense, higher antibodies = more thyroid destruction. The following symptoms were found to be higher in the patients with elevated TPO antibodies: chronic fatigue, dry hair, chronic irritability, chronic nervousness, dysphagia, and easily fatigued. Remember, the study participants all have normal thyroid hormone levels. The researchers also found that higher TPO levels were associated with an overall decreased quality of life. 

A patient recently told me that her endocrinologist lamented that Hashimoto’s is so ‘overblown’. This paper was published in 2011. It’s time we start listening to patients AND keeping up with the research. There is nothing overblown about Hashimoto’s and just treating thyroid hormones (TSH, FT3, FT4) isn’t enough for Hashimoto’s patients. We can do better. 

Epstein-Barr virus association with Hashimotos (https://pubmed.ncbi.nlm.nih.gov/32215255/) (2020)

Epstein Barr virus, one of the viruses that cause mononucleosis or ‘mono’, is considered a possible trigger of Hashimoto’s disease. This study investigated the prevalence of different types of antibodies to Epstein Barr virus (EBV) in people with Hashimoto’s thyroiditis (HT) and healthy controls. Approximately 95% of the adult population is infected during their life so not surprisingly, all participants tested positive for the antibody that measures if someone has been infected. What’s interesting is that the amount of antibodies present was significantly higher in the HT patients than in healthy controls. In addition, one of the antibodies, the early antigen IgG which is considered a marker of reactivation of the virus, was positive in HT patients at a significantly higher rate than controls. 

Review of Nutrients Needs In Hashimoto’s (https://doi.org/10.1967/s002449910507) (2017)

This review article published in 2017 provides an update from the literature regarding several key factors impacting Hashimoto’s. I will summarize their findings for each below. 

Iodine: Hashimoto’s is more common in areas that have plenty of iodine in the food supply/soil. Even small increases in iodine intake increase the risk of Hashimoto’s. The authors recommend discouraging excess iodine intake but caution that iodine levels of 250mcg daily are still required for pregnancy. Note from Dr. Barrett: this is a ‘goldilocks’ situation- you still need adequate iodine, just not too much. For non-pregnant patients I recommend limiting total iodine intake daily to 150mcg. 

Selenium: The thyroid tissue contains the highest concentration of the trace mineral selenium in our bodies. This mineral acts as an antioxidant and has anti-inflammatory properties. The exact mechanism of benefit to the thyroid has not been determined but we do know that it seems to modify the immune and inflammatory response. Three meta analyses have confirmed that selenium reduced TPO and TG antibodies. Selenomethionine is superior to sodium selenite because selenomethionine is absorbed more easily. The authors concluded that supplementing with selenomethionine is beneficial for Hashimoto’s patients. 

Vitamin D: This one is pretty straightforward. Vitamin D supplementation improves Hashimoto’s disease. The authors explain that the low cost and low side effect profile of 2,000- 4,000IU of vitamin D daily make it another good candidate to improve Hashimoto’s disease. 

Gluten: The authors argue that according to a recent meta analysis all patients with Hashimoto’s should be screened for celiac disease because of the high association between these two autoimmune conditions. “ In summary, whereas it is not yet clear whether a gluten- free diet can prevent autoimmune diseases, it is worth mentioning that HT [Hashimoto’s Thyroiditis] patients with or without CD [Celiac Disease] benefit from a diet low in gluten as far as the progression and the potential disease complications are concerned”. Note from Dr. Barrett: I think it’s warranted to try the gluten free diet in Hashimoto’s after screening for celiac disease.  

Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis (https://doi.org/10.1007/s00296-015-3278-1) (2015)

Hashimoto’s is an autoimmune condition that destroys the thyroid tissue and may lead to hypothyroidism. These two conditions are often lumped together but it’s possible to have Hashimoto’s and not develop hypothyroidism. This study investigated the presence of autoimmune thyroid disease in patients already diagnosed with rheumatoid arthritis (RA). Their aim was to determine if there is an association with chronic widespread pain (CWP) and/or fibromyalgia and autoimmune thyroid disease. Their findings are quite interesting. There is a strong association with the presence of one of the thyroid antibodies and CWP and fibromyalgia but not the other! Only TPO antibodies were associated with the increase in chronic pain in this population. Another interesting finding is that the association of TPO antibodies with fibromyalgia was independent of hypothyroidism. This is important because hypothyroidism can cause widespread pain so the assumption could be made that the association with this antibody and pain could be due to the low thyroid function. That isn’t the case. There is something about the presence of the TPO antibody that is the association with pain. I find these results important because patients are often told once their hypothyroidism is treated, their autoimmune thyroid symptoms should be resolved. This study supports the fact that many patients are still symptomatic even when their thyroid hormones have normalized. The authors conclude that testing for TPO antibody should be standard of care in RA patients to help determine risk of CWP and fibromyalgia. 

The association of other autoimmune diseases in patients with autoimmune thyroiditis (https://doi.org/10.1016/j.autrev.2016.09.009 ) (2016)

The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients.

This literature review found an increased prevalence of several autoimmune disorders when someone has autoimmune thyroid disease. The most common associations were Autoimmune thyroid disease + chronic autoimmune gastritis + vitiligo and Autoimmune thyroid disease + chronic autoimmune gastritis + polymyalgia rheumatica.

Other conditions that were more common alongside autoimmune thyroid disease include: rheumatoid arthritis, celiac disease, diabetes, sjogren disease, multiple sclerosis, systemic lupus erythematosus, sarcoidosis, alopecia, psoriatic arthritis, systemic sclerosis, and HCV-related cryoglobulinemia

Chronic autoimmune gastritis (CAG)  was the most commonly associated autoimmune disease with autoimmune thyroid disease. CAG is largely asymptomatic and can remain undiagnosed for a long time. Sometimes laboratory results can clue us in such as low iron and or low B12. Some people can feel generalized digestive upset, reflux and/or feeling full early.  CAG is diagnosed with antibody testing (parietal cell and intrinsic factor antibodies) and endoscopy. 


Reference:
1. Ott, Johannes & Promberger, Regina & Kober, Friedrich & Neuhold, Nikolaus & Tea, Maria & Johannes, Huber & Hermann, Michael. (2011). Hashimoto's Thyroiditis Affects Symptom Load and Quality of Life Unrelated to Hypothyroidism: A Prospective Case-Control Study in Women Undergoing Thyroidectomy for Benign Goiter. Thyroid : official journal of the American Thyroid Association. 21. 161-7. 10.1089/thy.2010.0191

2. Assaad SN, Meheissen MA, Elsayed ET, Alnakhal SN, Salem TM. Study of Epstein-Barr virus serological profile in Egyptian patients with Hashimoto's thyroiditis: A case-control study [published correction appears in J Clin Transl Endocrinol. 2020 Dec 17;23:100242]. J Clin Transl Endocrinol. 2020;20:100222. Published 2020 Mar 12. doi:10.1016/j.jcte.2020.100222
 
3. Liontiris, M. I., & Mazokopakis, E. E. (2017). A concise review of Hashimoto thyroiditis (HT) and the importance of iodine, selenium, vitamin D and gluten on the autoimmunity and dietary management of HT patients.Points that need more investigation. Hellenic journal of nuclear medicine, 20(1), 51–56. https://doi.org/10.1967/s002449910507 

4. Ahmad, J., Blumen, H. & Tagoe, C.E. Association of antithyroid peroxidase antibody with fibromyalgia in rheumatoid arthritis. Rheumatol Int 35, 1415–1421 (2015). https://doi.org/10.1007/s00296-015-3278-1
​
5.  Poupak Fallahi, Silvia Martina Ferrari, Ilaria Ruffilli, Giusy Elia, Marco Biricotti, Roberto Vita, Salvatore Benvenga, Alessandro Antonelli.The association of other autoimmune diseases in patients with autoimmune thyroiditis: Review of the literature and report of a large series of patients. Autoimmunity Reviews. Volume 15, Issue 12 (2016) Pages 1125-1128. ISSN 1568-9972,
https://doi.org/10.1016/j.autrev.2016.09.009 ​
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Atomic Habits: As Easy & Proven Way to Build Good Habits & Break Bad Ones By James Clear

2/9/2022

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I will start off by saying, read this book. James Clear makes an excellent argument that the quality of our lives depends on the quality of our habits. Once he has convinced you that habit change is life changing, he outlines many practical and small (atomic) ways to shift your habits. I am going to summarize two points from the book that really stuck with me.
 
Behavior changes starts with an identity change. 

Clear explains that one reason why we fail to stick with habits is that our self image gets in the way. We tell ourselves that we are trying to become a person who exercises daily instead of making the identity shift into believing that you are a person who exercises daily. This is the best way to be intrinsically motivated, if you identify as a fit person who enjoys exercise then the habit that sustains that identity becomes easier. One thing Clear wrote that really stuck with me on this topic is “every action you take is a vote for the type of person you want to become”. It sounds hyperbolic but when you really think about it, it rings true. 

Forget goals, focus on systems.
​

Clear emphasizes that systems are what keep our habits running and eventually lead us to our goals. There are a few issues with a goals first mentality. One issue is that it’s harder to live in the moment and enjoy your day to day life if you are just striving for a goal. Another issue is what happens when you hit your goal? Most of us don’t savor that feeling, we just move the milestone. Clear asks us to fall in love with the process, to savor the systems that keep us slowly moving towards the people we want to be. This way, as long as your systems are running you feel content and satisfaction. I’ve been trying this out for the last 6 weeks since I finished the book and I really like it. I’ve put systems in place (daily exercise, reading and meditation) without goals per se aside from putting in the time. Just knowing that my systems are running feels great! The quote from this section that I keep coming back to is “You do not rise to the level of your goals. You fall to the level of your systems.”
 
The book is filled with more concepts, these are just two that really stuck with me. This book has something for everyone. If you have struggled to make a habit change last I highly recommend reading Atomic Habits. ​
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Take Care of Yourself This Year

1/19/2022

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Photo from Pixels and Ahmad Taufik
As we enter our third year of the pandemic, the last thing we want to hear more about is healthcare. We’ve been inundated -- it’s all anyone can talk about. Personally, I would love to talk about travel, art shows, concerts and book clubs, all the things I miss!

Unfortunately, we still need to talk about healthcare because many Americans are missing critical healthcare screenings. At first, we just put them off not realizing how long the pandemic would last. Now, I think we are just collectively burned out regarding anything healthcare related. Even before the pandemic, my patients struggled to check all the boxes for preventative healthcare. I’ve put together a list below of routine healthcare screenings that I recommend. 

Annual physical exam 
Your primary care physician should perform a physical exam each year. This overall screening helps identify any concerns. This will include a screening for blood pressure.  Bloodwork is often ordered during this visit. 

There are many other screenings that are based on age including mammograms, colonoscopies, prostate exams and gynecological exams. Your primary care physician can help you determine when it’s appropriate to have these screenings done. 

Bloodwork 
What lab work to run annually is probably the most ‘controversial’ on my list because everyone has a different opinion. For example, some providers run vitamin D each year and others insist that it’s not worth it. Each provider is going to have their own opinion about what’s warranted each year.

Here’s mine: 
  • For someone who is generally healthy: Vitamin D, lipid panel, CMP, CBC, TSH, A1c. It’s a long list for a healthy person but catching something early or seeing a trend change over time is critical in preventing more serious illness. 
  • For someone with metabolic concerns or strong family history of metabolic disease: Vitamin D, lipid panel, CMP, CBC, TSH, A1c, insulin and maybe also CRP

For more details on some of the lab markers above check out my blog on ‘Knowing Your Numbers.’
 
Dental
Oral health is critical to our overall health. Too many of us skip regular dental exams. Cleanings are typically recommended every 6 months with x-rays every year. Talk to your dentist about what’s right for you. 

Eye Exams
These are particularly important if you have blood sugar dysregulation or family history of glaucoma. Many Americans need glasses and don’t realize it. So if it’s been a few years make an appointment with your eye doctor so they can weigh in about just how often you should be screened. 

Skin Exams
I recommend annual skin exams at your dermatologists office. If you have many moles or very fair skin you may need to be screened more often. Your dermatologist can help you determine the appropriate frequency of visits. 


It’s a lot, I know, but you’re worth it! There are a few strategies you can employ to help you remember to get these appointments checked off your to-do list.

One option is to pick a ‘health month.’ For example, if January is your health month you would schedule your eye exam, physical, skin check, etc. in January each year.

Another option is to assign each check up to a month. Maybe your annual physical is in January every year. Then you have your eyes checked each February and so on. 

Early screenings and regular check ups save lives. Please make a plan and talk to your doctor about which screenings are appropriate for you.
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Is Poor Sleep A Root Cause for Your SymPtoms?

12/6/2021

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American’s are underslept. I knew this before I read Why We Sleep by Matthew Walker, Phd but I didn’t fully grasp the health implications. Dr. Walker opened my eyes to the staggering statistics regarding sleep in our country and how insufficient sleep increases our risk for a whole host of health concerns. 

An excerpt from Dr. Walker’s book reads “Scientists have discovered a revolutionary new treatment that makes you live longer. It enhances your memory and makes you more creative. It makes you look more attractive. It keeps you slim and lowers food cravings. It protects you from cancer and dementia. It wards off colds and the flu. It lowers your risk of heart attacks, stroke, not to mention diabetes. You’ll even feel happier, less depressed and less anxious. Are you interested?” The evidence to back up these claims has been well documented. You just need adequate sleep. 

Unfortunately, 1 in 3 US adults fail to achieve the absolute minimum of 7 hours of sleep per night. 

Insufficient sleep impacts all the major physiological systems of the body, this includes our cardiovascular, immune, reproductive, and metabolic systems. Lack of sleep increases our risk for cancer, cardiovascular disease, diabetes, and dementia. Insufficient sleep also shortens our lifespan.  

I screen every patient for sleep quality and length. In my experience, many patients dismiss lack of sleep as a possible root cause of disease, they want to talk about "more important" things such as changing their diet. I am here to tell you, sleep is just as important (likely more so!) than what you eat. I am often debunking common misconceptions about sleep. Some think they can just ‘make it up’ on the weekends (spoiler, you can’t!). Others feel they function "great" on less than 7 hours of sleep. We even have a new term ‘revenge bedtime procrastination' because so many of us are staying up late looking for a little downtime in our busy schedules and missing out on critical sleep time. 

Sleep is the fundamental need for our bodies that all other aspects of our health are built on. If you read this far and you still think that you can skimp on sleep and remain unscathed I urge you to read or listen to Dr. Walker’s book. It was eye opening. 

I think one reason patients can be convinced that their lack of sleep isn’t impacting them is that their baseline of health has shifted and they don’t realize it. Dr. Walker wrote “With chronic sleep restriction over months or years, an individual will actually acclimate to their impaired performance, lower alertness and reduced energy levels. That low-level exhaustion becomes their accepted norm, or baseline. Individuals fail to recognize how their perennial state of sleep deficiency has come to compromise their mental aptitude and physical vitality, including the slow accumulation of ill health.” In other words you don’t realize how good you could feel with adequate sleep. 

With the advent of wearable technology, we have a whole new way of gathering data about ourselves. It’s been interesting for me to look at my sleep data overlaid with my stress levels (I picked my tracker particularly for the HRV data). I can absolutely see a correlation with nights that I sleep poorly and elevated levels of stress. I am a sucker for data but you don’t need a sleep tracker to optimize your sleep. Dr. Stamer wrote a great article with some tips for getting a good nights sleep. You can read that article here. 


Having read a small summary about how sleep deprivation can be a root cause of your illness I hope it empowers you to take a closer look at your sleep and make sleep a priority. 





References:
  1. Matthew Walker, PhD (2017) Why We Sleep Unlocking the Power of Sleep and Dreams
  2. CDC article “1 in 3 adults don’t get enough sleep” Accessed 11/13/2021 https://www.cdc.gov/media/releases/2016/p0215-enough-sleep.html 
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Therapeutic Baths

11/17/2021

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Photo by Karolina Grabowska from Pexels

Warm baths are actually good for your health.

That’s right, a simple soak in warm to hot water actually has proven health benefits. These benefits include improving blood circulation, relaxing muscles, improving sleep quality, and reducing stress. 

When I prescribe baths for my patients I recommend adding 2 cups of Epsom salts to the tub.  Epsom salts are a particular type of salt mined from a spring in England. Epsom salt breaks down to magnesium and sulfate in water. Historically, epsom salts have been used for a laundry list of ailments from sore muscles to enhanced detoxification. Epsom salt baths are another traditional therapy that we don’t have the science to back up (yet!).

Anecdotally, adding Epsom salt to baths appears to increase the therapeutic benefit of a bath. I’ve heard all sorts of theories about how Epsom salt improves our health. There is one myth I want to dispel. Some folks are under the impression that the Epsom salt in a bath can somehow pull toxins from our tissues into the bath water. Not only is there no evidence to support this, it’s biologically improbable. What I suspect is happening is that we are absorbing some of the magnesium and sulfate in the water. This theory is also unproven but a small report in 2014 did show a modest increase in sulfate and magnesium in the blood after an Epsom salt bath. Magnesium is necessary for over 300 biochemical reactions in our body. We don’t know exactly how the magnesium moves from the water across our skin and into our tissues but that’s the main theory behind the additional benefit of adding Epsom salt to the bath water. 

When I recommend Epsom salt baths I instruct patients to add 2 cups of salt to the bathtub, allow the salt to dissolve (4 minutes or so) and then soak for 20-30 minutes. I encourage patients to take an Epsom salt bath 2-3x per week in the evening. 

I recommend Epsom salt baths to patients regularly for a variety of reasons:
  • Forces folks to slow down and relax even if it’s just 20 minutes
  • The warm bath will likely improve their sleep quality that night
  • It may increase their tissue levels of magnesium
  • Soothes sore muscles and joints
  • Likely improves gentle detoxification via increased magnesium 

Some reasons to be cautious or skip Epsom salt baths:
  • Low blood pressure, high blood pressure, POTS, or orthostatic hypotension: warm baths relax your blood vessels and increase your heart rate both of which can cause changes to your blood pressure. If you have any of these conditions be cautious getting out of the tub and make sure someone is nearby to help you in case you feel faint. I also recommend just a warm bath instead of a hot bath in these cases. 
  • Sulfate allergy: the sulfate in the water could cause hives

In summary, Epsom salts are a low cost and safe addition to a therapeutic warm bath. 



References: 
  1. Hoekstra, S. P., Bishop, N. C., Faulkner, S. H., Bailey, S. J., & Leicht, C. A. (2018). Acute and chronic effects of hot water immersion on inflammation and metabolism in sedentary, overweight adults. Journal of applied physiology (Bethesda, Md. : 1985), 125(6), 2008–2018
  2. http://www.epsomsaltcouncil.org/wp-content/uploads/2015/10/report_on_absorption_of_magnesium_sulfate.pdf
  3. https://www.epsomsaltcouncil.org/faq/
  4. https://health.clevelandclinic.org/reasons-to-take-a-bath/​
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Calming Evening Drinks

10/20/2021

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Picture
Jennifer Pallian on Unsplash
This is a follow up to my recent blog post on alcohol titled, "Are You Drinking Too Much?" That article prompted some interesting conversations with patients. Many folks use alcohol in the evenings as a way to ‘unwind’ after a long day. With so many of us working from home, pouring an alcoholic beverage can be that ritual that signals the work day is over. Ritual is important and having a ritual of crafting a beverage for yourself at the end of the day is lovely. I found myself helping patients concoct an alcohol-free version of a drink that helps them relax without the negative impact of alcohol. I am going to share some ideas with you below - happy (alcohol-free) drinking!

My relaxing beverage changes with the seasons. Something warm is soothing in the colder winter months but I love a sparkling and refreshing mocktail in the summertime. 

My go-to in the winter time is warm tea. There are so many fantastic relaxing herbs to choose from. I will list a few of my favorites that I like to drink alone or blended together:
  • Tulsi 
  • Ashwagandha
  • Chamomile
  • Lemon balm
  • Passionflower

Don’t forget you can mix tea bags together. I often add a bag of hibiscus tea to improve the flavor of whatever herbal tea I’m drinking. Also consider buying combination blends. 

If you want to increase the relaxation power of your tea consider adding some L-theanine powder and/or magnesium powder. 

L-theanine is an extract from green tea that increases alpha waves. This means that L-theanine helps you feel relaxed without causing drowsiness. You could try using a decaffeinated green tea or you can open a capsule of L-theanine and dump the powder into your beverage. I recommend using 100-200mg of L-theanine. 

Magnesium is a mineral that has a calming effect. I personally use ‘Natural Calm Powder’ aka magnesium citrate powder regularly in an evening beverage to help me relax after a long day. You can pick up an unflavored magnesium powder so it’s easy to add to a warm beverage or a ‘mocktail.’ Note: magnesium may cause loose stools in large quantities so be careful with your dosing and start with 100-300mg. 

If tea isn’t for you, try Golden Milk, a lovely blend of warm milk, honey and spices. 

Use relaxing herbs to boost your mocktail.
In the warmer months I enjoy putting together a ‘mocktail.’ I keep tinctures of chamomile, lemon balm, passionflower, valerian, and kava kava* on hand. My favorite way to make a refreshing mocktail is to mix some sparkling water (flavored or unflavored) with some tart juice and add a few droppers of a tincture. A tincture is a concentrated herbal extract in alcohol. You will get about ½ tsp of alcohol using this recipe so please skip this if you struggle with alcohol addiction. I listed the tinctures above in order of ‘strength’ for their ability to help you relax. The tincture also adds a little bite and helps it taste like an actual cocktail. Consider using tart cherry juice in your mocktail. Tart cherry has been shown to boost melatonin levels.

Since we want to lean into the power of a ritual, use a fun glass! If there is something about holding a wine glass that really helps you shift into ‘home mode' then use a wine glass for your new beverage of choice. 

What helps you unwind at the end of the day?



*Caution with Kava kava root. Please do not combine with alcohol and don’t use this tincture daily. It can damage your liver (just like alcohol!) if you use it daily for longer than 3 months. 
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Vitamin Nature

9/8/2021

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Picture
Photo by James Wheeler on Unsplash
We are heading into my favorite season, Fall! It’s the time of the year I like to spend hours at a time outdoors. Being in nature feels good for my body, mind and spirit and science backs up that feeling. I have heard nature referred to as ‘Vitamin N’ and I love it! A vitamin is defined as an organic substance that is essential to the nutrition of most animals. While time in nature isn’t really essential for nutrition, in my opinion it is essential for optimal human function. 

Spending time in nature has physical benefits including a reduced heart rate, muscle tension, and blood pressure as well as a reduction in stress hormones. That’s not all, researchers at Tokyo’s Nippon Medical School found an increase in the white blood cells that fight viruses and cancer in women who spent 6 hours in the woods over the course of a two-day period. The increase in white blood cells lasted at least 7 days after their nature exposure. 

Spending time in nature improves mood. We move from depressed, stressed and anxious to more calm and balanced. This is the main reason I turn to nature. In our overstimulating world nature offers a sense of calm that is incredibly grounding and so needed.  
 
‘Forest bathing’ or Shinrin-yoku was developed in Japan in the 1980’s and has become a cornerstone in Japanese medicine. The concept is simply to visit a natural area and walk in a relaxed way to enjoy health benefits. The proven benefits are long and include a bolstered immune system, improved recovery from surgery, improved sleep and reduced stress.

I am often prescribing vitamin N to my patients and it doesn’t have to be a large dose. The Shinrin-yoku research has found that the sweet spot is 2 hours per week which is roughly 20 minutes per day. 
 
A 2015 study published in the International Journal of Environmental Research and Public Health  found that even looking at pictures of green space for 5 minutes increased parasympathetic activity (calm) after a stressful event. It’s pretty incredible that even pictures of nature can reduce your stress. If you can’t get yourself outside more often, consider adding nature images to your home and workplace.

Ideas to increase your dose of vitamin nature:
  • Take a less urban route when driving.
  • Eat your lunch outside
  • Go for a walk around the block
  • Read in the grass
  • Walk on a less urban street or make a point to walk near or in a park.
  • Find windows in your home or office that overlook nature and make a point to look outside and appreciate what you see.
  • In the wintertime if you are cold sensitive, spend time in a conservatory such as Como Park in St. Paul.
  • Get physical outside, make a point to run outside vs on a treadmill
  • Put a bird feeder outside a window that is easily visible and make a point to appreciate the animals that stop by.
  • Add plants to your home and office.
  • Garden! Consider a community garden if you don’t have a yard.
  • Make sure you have natural light entering your home.


References
  1. Li Q, Morimoto K, Kobayashi M, et al. A forest bathing trip increases human natural killer activity and expression of anti-cancer proteins in female subjects. J Biol Regul Homeost Agents. 2008;22(1):45-55
  2.  Pearson DG, Craig T. The great outdoors? Exploring the mental health benefits of natural environments. Frontiers in Psychology. 2014;5:1178. doi:10.3389/fpsyg.2014.01178.
  3. van den Berg MM, Maas J, Muller R, et al. Autonomic Nervous System Responses to Viewing Green and Built Settings: Differentiating Between Sympathetic and Parasympathetic Activity. Int J Environ Res Public Health. 2015;12(12):15860-15874. Published 2015 Dec 14. doi:10.3390/ijerph121215026
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    Dr. Barrett

    is a naturopathic doctor specializing in treating autoimmune disease, chronic ailments, hormone imbalance, and digestive concerns. This blog is an archive of her ongoing research in these areas.

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